The crash occurred at about 10:20 p.m. at the intersection of state Highway 4, known as Main Street within the city, and Cypress Road when a Buick sedan and a Dodge pickup truck collided, Thorsen said.
Two victims, a 57-year-old man and his 35-year-old son, were trapped inside the wrecked Buick and rescue workers had to cut them out of the car with the Jaws of Life, officials said.
One was airlifted to John Muir Medical Center and the other was flown to University of California, Davis Medical Center, Contra Costa County sheriff's Lt. Jeff Jennings said.
A third passenger in the Buick, a man in his 50s, suffered minor injuries. He was taken to Sutter Delta Medical Center in Antioch by ground ambulance, where he was treated and released, Thorsen said.
The female driver of the pickup was also taken to Sutter Delta with minor injuries. She was treated and released as well, Thorsen said.
The cause of the crash is still under investigation, Thorsen said, but so far it does not appear that alcohol was involved.
The roadway was closed for close to eight hours as police investigated the scene. It was reopened at about 6:30 a.m. today, officials said.
