Officers received reports of a Nissan Sentra striking the center divide and then the guardrail, west of Cummings Skyway, just before 10 Tuesday night.
A witness told officers that the driver and the car appeared to have been shot several times.
The driver was a 24-year-old Vallejo man who died from gunshot wounds. Three lanes of Interstate 80 were closed for several hours while the CHP investigated the shooting.
If you have any information please call 1-800 TELL CHP.