After 25 years on the air, the talk show host, with the help of her magazine, is cleaning out her closet for charity.
She will auction off 150 items of clothing, accessories and shoes on eBay.
Some of the items, such as a pair of Prada wedges, were shown off on Good Morning America Wednesday.
The money raised will benefit Oprah Winfrey's leadership academy in South Africa.
The auction runs March 1 through March 11.