A disturbance involving a weapon was reported at a two-story townhouse in the 100 block of Rose Lane, near Capitol Expressway, at 11:47 a.m., Sgt. Ronnie Lopez said.
"Upon arrival officers heard some shots being fired," Lopez said.
Officers began evacuating nearby homes and surrounded the townhouse where the disturbance occurred.
Police are now trying to communicate with two people believed to be inside the home, a male and a female, Lopez said.
"We're attempting to make contact with them, we're not sure what their status is," Lopez said at about 1:30 p.m.
It is not clear whether anyone was hit by the gunfire.
The owner of nearby Mark's Hot Dogs, who declined to give her name, said her parking lot was full of police cars and that she and others weren't being allowed outside.
She said she had heard what may have been gunshots after police arrived, but initially assumed the sounds were coming from nearby auto shops.