The shooting occurred at about 8:55 p.m. on northbound I-680 just south of McKee Road when the driver of a white Chevrolet Trailblazer shot at a silver Dodge Durango.
Four shots pierced the sport utility vehicle, striking a passenger riding in the back seat once in the back, the CHP said.
The suspect, described by the CHP as a Hispanic male in his 20s with a black goatee and mustache wearing a black hooded sweatshirt, then fled the scene by exiting the freeway onto McKee Road.
The male victim was transported to Regional Medical Center for treatment of his gunshot wound.
A Hispanic female with curly black hair was seen riding in the passenger seat of the Chevrolet, the CHP said.
Anyone with information regarding this shooting is asked to contact the CHP San Jose area office at (408) 467-5400.