The third movie in the Pixar series about cowboy Woody, space ranger Buzz Lightyear and the toys' owner, Andy, has crossed more than $920 million at box offices worldwide since opening June 18, according to Disney.
That means it edged out DreamWorks Animation SKG Inc.'s "Shrek 2" to attain the top spot.
The movie also ranks as Disney's fourth highest-grossing film of all time.
Its top grossers are "Pirates of the Caribbean: Dead Man's Chest" (2006) at $1.07 billion, "Alice in Wonderland" (2010) at $1.02 billion, and "Pirates of the Caribbean: At World's End" (2007) at $961 million.
Pixar introduced the "Toy Story" characters in 1995 and the movies have made more money with each incarnation.
The first in the series grossed $362 million, and the second $485 million, according to Box Office Mojo.
The Walt Disney Co. bought Pixar for $7.4 billion in stock in January 2006.