Someone called police at about 6:50 a.m. to report finding a man on the side of the road at Zanker and Los Esteros roads in the city's Alviso community, Officer Jose Garcia said.
He said it appears the cyclist was hit by a car on his way to work. He was pronounced dead at the scene.
Garcia said officers were not able to locate any witnesses at the scene.
Anyone who may have seen the hit-and-run is asked to call the Police Department's traffic investigations unit at (408) 277-4654. Those wishing to remain anonymous can call Crime Stoppers at (408) 947-STOP (7867).