The truck, which was carrying 43,000 pounds of molten wax, overturned at the Cochrane Road exit at about 2:45 p.m. Monday, CHP Officer Peter Van Eckhardt said.
The driver, a 50-year-old man from Gonzales, was taken to Regional Medical Center of San Jose after complaining of pain.
Crews siphoned the molten wax from the crashed tanker to another truck and then uprighted and removed the tanker from the highway overnight, CHP Officer Jaime Rios said.
All lanes were reopened by the morning commute.
The crash damaged an asphalt curb and callbox, Rios said.
Southbound traffic was at a near standstill while crews worked to clear the crash scene.
"Traffic was backed up pretty badly," Rios said.
The CHP does not believe alcohol or drugs played a role in the crash.