Units responded to reports of a crash involving a white sport utility vehicle and gold sedan on eastbound Highway 580 near Dutton Avenue at 6:05 a.m., CHP Officer Eric Anderson said.
One person was killed in the crash and at least one more has been taken to a hospital with injuries, Anderson said.
Eastbound traffic was diverted off the highway at 106th Street while authorities clear the crash.
A Sig-alert was canceled at 8:45 a.m.