The shooting was reported at about 3:20 a.m. in a parking lot at Christmas Tree Point, a vista point that looks out on downtown San Francisco, police Sgt. Michael Andraychak said.
The victim, a man in his early 20s, suffered multiple gunshot wounds and was pronounced dead at the scene, Andraychak said.
His identity is not being released until his family is notified of the death, according to the medical examiner's office.
The victim was with a group of friends, and there was also another group nearby in the parking lot, Andraychak said.
After some sort of verbal dispute between the two groups, at least one suspect in the other group shot at the victim.
The suspects, described only as two or three white or Hispanic males, fled in a white Honda Odyssey, Andraychak said.
Anyone who has information about the shooting is asked to call the San Francisco Police Department's homicide unit at (415) 553-1145 or the anonymous tip line at (415) 575-4444, or text information to TIP411.