The crash happened at about 10:50 a.m. on eastbound Highway 4 just east of Interstate Highway 80, near Willow Avenue.
CHP Officer Kevin Bartlett said it appears the man being transported became combative inside the car, which may have contributed the crash.
He did not have details on the crash but said a Honda Accord was also involved.
Two people were sent to hospitals, including one who was taken to John Muir Medical Center with minor injuries.
The crash initially blocked lanes, but the roadway was cleared just before noon.