The crash occurred around 5:30 a.m., when a red Honda civic was rear-ended by a 1960s or 1970s model pickup truck, according to CHP Public Information Officer Art Montiel.
The Honda and was struck a second time by a taxicab. The Honda sustained severe damage and the driver was killed. The San Mateo County coroner's office has identified the driver as Jacqueline Thompson, 37, of Daly City.
The pickup truck fled the scene. It was described as an older model Ford, tan or rust in color, with significant front-end damage.
The crash blocked southbound 101 for nearly three hours.
Anyone with information on this crash or the suspect vehicle should call 911.