Michelle Henry, 42, was driving a Buick Lucerne on westbound Interstate Highway 80 near Air Base Parkway at about 5:20 a.m., the CHP said.
Henry was allegedly traveling at high speed when she struck the rear of a Ford Explorer, causing both vehicles to overturn, the CHP said.
The Buick landed in some bushes on the right shoulder, and the Explorer rolled across two lanes of traffic and came to rest on its roof, the CHP said.
As one of the passengers in the Explorer - a 25-year-old Sacramento man -- got out of the vehicle to help another passenger, a Toyota struck the rear of the vehicle causing it to strike him.
The man was thrown into westbound traffic and killed, the CHP said.
The driver of the Explorer, a Sacramento man, was also killed.
The Solano County coroner's office had not released the victims' identities as of this afternoon.
Henry, who suffered minor injuries, was arrested for felony drunk driving and possession of a loaded firearm.