Around 9:30 p.m., the two inmates made it past security fencing and fled, while a third suspect attempted to escape but was apprehended, sheriff's officials said.
The detention facility is located at 2254 Ordinance Road, near the Sonoma County Airport.
The inmates have been identified as Serefino Uriel Gonzalez, 42, and Rene Solorio Leon, 22, both of Santa Rosa.
Gonzalez is described as 5 feet 8 inches tall and roughly 200 pounds, with brown eyes, black hair and a goatee and mustache.
Leon is described as 5 feet 5 inches tall and about 200 pounds, with brown eyes, black hair and a moustache.
Both inmates were last seen wearing blue denim shirts and blue jeans with jail markings.
They were serving sentences for drug and alcohol violations.
The inmates should be considered dangerous. Anyone who sees them is asked to call the Sonoma County sheriff's dispatch line at (707) 565-2121.