Officers responded to reports of a collision involving a bicycle rider in the 1100 block of Cortez Avenue at about 12:15 p.m., according to the Burlingame Police Department.
Preliminary information indicated that the bicyclist was heading south alongside the truck when he attempted to turn left, police said.
He hit the side of the truck and was run over, police said. The victim was pronounced dead at the scene.
The truck driver stopped at the scene and cooperated with police.
There was no indication that a crime contributed to the crash, police said.
The victim's name was not released pending notification of his family.