The collision was reported at 5:50 p.m. on state Route 12, CHP Officer Chris Parker said.
A Toyota pickup truck was driving east and attempting to make a left turn into a driveway across the road.
But while making the turn, the driver saw a motorcycle coming towards the pickup. The pickup's driver attempted to accelerate to get out of the way of the motorcycle, but did not make it across the highway in time and the motorcycle struck the rear of the truck.
The motorcyclist was thrown from the bike and hit the front of a Honda driving on the other side of the road.
The motorcyclist was pronounced dead at the scene, and identified as an off-duty CHP officer, Parker said.