The shooting occurred in the 3800 block of East 52nd Street at approximately 3:30 a.m.
Police say the victim, identified as a 26-year-old Hispanic male, was shot one time in the upper torso and died at the scene.
His identity has not been released pending notification of kin.
The motive for the shooting remains unknown. Police have no suspect or vehicle information.
Anyone with more information regarding the murder was asked to contact the sheriff's homicide bureau at (323) 890-5500.