The pedestrians were walking south on Fillmore Street just after 2 a.m. when they were struck by a vehicle traveling west on Green Street, according to police.
The suspect fled the scene, leaving one pedestrian with life-threatening injuries and the other with non-life threatening injuries, police said.
Evidence left at the scene suggests the suspect vehicle was a dark-colored 2008-2012 Honda Accord sedan. The vehicle would have procured major damage to the right front headlight, right fender, right side hood and passenger side windshield, police said.
Anyone with information on this incident or the suspect vehicle is asked to contact police at (415) 57-4444 or text a tip to TIP411, starting the message with SFPD.