Crews have set over 1,100 detonation charges on the old Warren Hall Administration Building. That's 463 pounds of explosives.
Saturday's demolition will make the 13-story landmark building crumble away from the adjoining library.
Officials decided to blow up the building, instead of tearing it down slowly, to keep dust to a minimum.
"You have the same quantity of dust, but that dust is limited to a few minutes on a given day, with a known time, with proper planning so that same quantity of dust can be dealt with effectively," said Mark Liozeaux with Controlled Demolition Inc.
Geologists from the USGS were also busy Thursday afternoon placing 600 sensors around the East Bay to measure movement along the Hayward Fault.
The blast will have the same energy as a 2.0 quake.
ABC7 News will be streaming the implosion live on Saturday at 9 a.m.