Officers spotted a car suspected of being connected to a robbery in the area of King Road and Alum Rock Avenue around 1 a.m., Officer Albert Morales said.
After a failed attempt at a traffic stop, the car fled at a high rate of speed. The car ultimately crashed in the area of Wilshire Boulevard and King Road, less than a half mile away, Morales said.
The suspect was shot at least once during a confrontation with police.
He was taken to hospital where he's being treated for his injuries.
A search for a second suspect is underway.
The second shooting happened near San Carlos and Lincoln Avenue where an officer shot at another robbery suspect after he refused to put down his gun.
The suspect was not hurt and was taken into custody.
Bay City News contributed to this story.