Derrick Shao was last seen at about 10 a.m. Thursday in the 900 block of Ingerson Avenue in the city's Bayview District. He was heading out to catch the 29-Sunset Muni bus to the school, according to police.
However, Shao never arrived at City College and has not been in contact with family or friends since then, police said.
He is described as Asian, about 5 feet 10 inches tall and 185 pounds, with brown eyes and black hair. He was last seen wearing black-rimmed glasses, a dark blue North Face pullover jacket, dark jeans, and red, black and white Nike shoes, police said. He was carrying a black JanSport backpack.
Shao, who speaks English and Cantonese, lives with his family and does not have a history of going missing, according to police.
Anyone with information about Shao's whereabouts is asked to call the Police Department's operations center at (415) 553-1071 or the Bayview Station at (415) 671-2300.