The crash was reported at about 12:10 p.m. when a white pickup truck struck the center divide on southbound Highway 280 about a mile north of an off-ramp to Foothill Expressway, CHP Officer James Evans said.
Preliminary information indicates that as many as two other vehicles were involved in the crash, and one person has been confirmed killed, Evans said.
An air ambulance and other emergency units were responding to the scene, Evans said.
A Sig-alert was issued at 12:41 p.m.
