Officers responded to a report of a burglary at a home in the 2900 block of Fleetwood Drive at about 12:15 p.m. Thursday, police said.
The resident of the home told investigators he had returned home and found the residence was burglarized and a window in the back of the home had been broken, according to police.
Officers searched the area but were unable to find any suspects.
Police are continuing to investigate a recent rash of home burglaries in the city. The department is asking the public to quickly report any suspicious activity by calling 911 and leaving a detailed description of the individuals and their cars, if any.
Anyone with information about Thursday's burglary is asked to call San Bruno police at (650) 616-7100.