The explosion happened around 8:30 p.m. Saturday in front of 131 West 23rd Street, between Sixth and Seventh avenues.
Twenty-eight of the people hurt suffered minor injuries, and one person's injuries are being described as serious. All 24 patients taken to area hospitals have been treated and released.
Debris landed on nearby cars and shattered some windows. Two cars on West 23rd Street and Sixth Avenue had their back windows blown out. An 8-year-old who was in the back seat was injured.
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The incident was captured on multiple surveillance cameras.
Mayor Bill de Blasio said that while the blast appeared to be intentional, it does not appear to be linked to terrorism.
Police said surveillance video recovered from West 23rd Street shows the explosion, and contains other evidence that indicates to investigators that the original object was intentionally left next to a construction trash container.
The object is described as four feet by four feet by three feet in size. In one video obtained by police, they see a man crossing the street in the vicinity of where the original object was left. The trash container was blown clear into the street by the force of the blast.
The object left behind could be a large tool box, and was left next to one of several commercial trash containers in front of a building that has been under construction. Investigators are trying to determine if there is a connection to this construction site.
"Now, I want to be clear: Whatever the cause, whatever the intention here, New Yorkers will not be intimidated," the mayor said. "We are not going to let anyone change who we are or how we go about our lives."
The FBI and Homeland Security officials, along with the Bureau of Alcohol, Tobacco, Firearms and Explosives arson and explosive task force, were all at the scene.
Police confirmed that a second device was found hours later on West 27th Street -- four blocks from the scene of the first explosion.
Watch the full briefing from official on the night of the explosion:
VIDEO: NYC officials provide update after blast in Chelsea
The reports of a possible blast came hours after a pipe bomb exploded in Seaside Park, New Jersey, shortly before thousands of runners participated in a charity 5K race to benefit Marines and sailors. Mayor de Blasio said there is no connection between the explosions.
New York City officials are urging anyone who saw or heard something to call 800-577-TIPS.
Click here for the latest on the explosion in Manhattan.
LATEST: NY Gov. Cuomo orders additional 1,000 officers to sites across the state "out of an abundance of caution." pic.twitter.com/Jdx642ZBFQ— ABC News (@ABC) September 18, 2016
Police looking into silver minivan on 27th between 6 & 7th Ave. Keeping everyone back. pic.twitter.com/LFbbh2aJfT— CeFaan Kim (@CeFaanKim) September 18, 2016