Sunday, 1 p.m. EDT, Fox
OPENING LINE: 49ers by 3 1/2, according to FanDuel SportsBook
AGAINST THE SPREAD: 49ers 0-1; Eagles 1-0.
SERIES RECORD: 49ers lead 19-14-1.
LAST MEETING: Eagles beat 49ers 25-20 on Oct. 4, 2020, in San Francisco.
LAST WEEK: 49ers beat Lions 41-33; Eagles beat Falcons 32-6.
49ERS OFFENSE: OVERALL (5), RUSH (11), PASS (10), SCORING (1).
49ERS DEFENSE: OVERALL (25), RUSH (17), PASS (25), SCORING (T-25).
EAGLES OFFENSE: OVERALL (6), RUSH (2), PASS (16), SCORING (9).
EAGLES DEFENSE: OVERALL (7), RUSH (19), PASS (2), SCORING (2).
TURNOVER DIFFERENTIAL: 49ers: minus-1; Eagles: even.
49ERS PLAYER TO WATCH: WR Deebo Samuel had nine catches for 189 yards and one TD last week vs. Detroit.
EAGLES PLAYER TO WATCH: Rookie WR DeVonta Smith had six catches for 71 yards and one TD in his NFL debut. He's facing a secondary that lost starting CB Jason Verrett for the season to a knee injury.
KEY MATCHUP: 49ers TE George Kittle vs. Eagles LBs. Kittle caught 15 passes on 15 targets for 183 yards and one TD vs. Philadelphia last season.
KEY INJURIES: The Niners lost two starters to season-ending knee injuries in the opener with running back Raheem Mostert and cornerback Jason Verrett both going down. Eagles safety Marcus Epps suffered a concussion in the opener. Wide receiver J.J. Arcega-Whiteside injured his ankle.
SERIES Game notes
The Eagles have won consecutive games in the series and seven of the past nine matchups since 2005. ... The teams last met in Philadelphia on Oct. 29, 2017. The Eagles won 33-10 on their way to their only Super Bowl championship.
STATS AND STUFF: Niners QB Jimmy Garoppolo has a passer rating of 100-plus in six of his past eight road starts. ... Niners rookie QB Trey Lance threw a TD pass on his first career attempt last week, joining Matt Ryan and Tim Tebow as the third rookie to do so since 2000. ... Niners RB Elijah Mitchell became first rookie in franchise history with 100 yards rushing in NFL debut. ... Niners WR Deebo Samuel has 100 yards receiving in three of his past four road games. ... Niners DL Nick Bosa had a sack and three tackles for loss in Week 1. ... New Eagles coach Nick Sirianni won his debut. ... Eagles QB Jalen Hurts had a career-high 126.4 rating last week. ... Eagles WR Jalen Reagor had career-high six catches for 49 yards and his second career TD catch in Week 1. ... Eagles DE Brandon Graham had seven sacks in eight home games last season. He has sack in three of his four career games vs. San Francisco. ... Eagles DT Javon Hargrave had two sacks last week.
FANTASY TIP: Although the Eagles held TE Kyle Pitts to four catches last week, Kittle is a sure bet to have a productive day even if he doesn't match his spectacular performance against Philly last season.
Bart Scott bets an eyebrow the 49ers will beat the Eagles
Bart Scott says he will shave an eyebrow off if the 49ers lose to the Eagles.