The fire broke out just before 10 p.m. Saturday at a three-story residential building on 8th Avenue between Noriega and Ortega.
Firefighters say a woman died. They believe she was in the building where the fire started. One firefighter was injured battling the flames, but is expected to be okay. More than 100 firefighters were on the scene at one point, and crews say the fire was difficult to put out.
"When we show up on the street address in front and the building is built down in the hill in the back we have to go down towards the fire and fight that heat. It's very dangerous and a harrowing situation," said San Francisco Fire Department Asst. Chief Kevin Burke.
Neighbors say an elderly woman lives in the bottom unit with her son. It's unclear if she is the person who died.
"It came to a point where it was pitch black and the officers were just telling us the smoke was just too dangerous and that we should go back in our houses but I just came out again. The wind picked up and right now I'm just checking to see if my friend is ok," said Joe Rivera, witness.
The Red Cross is helping those displaced by the fire.