The Raiders (1-1) held Mahomes in check for the opening 15 minutes before he carved up an overmatched defense with big play after big play in the second quarter for the Chiefs (2-0).
Mahomes didn't take long to strike, finding Demarcus Robinson open on a blown coverage for a 44-yard touchdown pass on the first play in the second quarter. He didn't slow down from there.
After the Raiders opted to punt on a fourth-and-1 near midfield, Mahomes and the Chiefs marched 95 yards and scored when Mahomes found rookie Mecole Hardman on a 42-yard deep strike for his first career catch to give Kansas City a 14-10 lead.
The Chiefs didn't stop there with Mahomes connecting on two more long TD passes in the final two minutes of the half, a 27-yarder to Travis Kelce and a 39-yarder to Robinson as the absence of injured star Tyreek Hill did little to slow Kansas City.
Mahomes finished 30 for 44 for 443 yards. Robinson had six catches for 172 yards and two scores and Kelce had seven catches for 107 yards and a TD to give the Chiefs their ninth win in the past 10 meetings in this long-time rivalry.
The Raiders had broken out to a 10-0 lead with a field goal on the opening drive and a 4-yard TD pass to Tyrell Williams later in the first quarter. But Carr also threw an interception in the end zone on a pass to Williams in the third quarter and the Raiders didn't score over the final three periods.
BY THE NUMBERS
Mahomes' 278 yards passing in the second quarter were the most for a player in any quarter since Drew Brees had 294 in the fourth period against Atlanta on Nov. 9, 2008. Mahomes ended the quarter with a bang, with his last five pass attempts each going for at least 27 yards, with TDs to Hardman, Kelce and Robinson. The streak extended with a 28-yarder to Robinson on the first play of the third quarter before Mahomes finally threw an incompletion.
Carr became the Raiders' all-time passing leader on a 16-yard pass to Darren Waller in the second quarter, breaking the mark of 19,078 set by Hall of Famer Ken Stabler. Carr finished the day 23 for 38 for 198 yards with one TD and two interceptions. He has 19,196 yards in his career.
Chiefs: LT Eric Fisher left on the opening drive after reinjuring his groin that he hurt in practice on Friday. Cam Erving replaced him.
Raiders: Returner Dwayne Harris injured his left ankle covering a punt in the second quarter and didn't return.
Chiefs: host Baltimore in home opener Sunday.
Raiders: begin a long stretch away from home at Minnesota on Sept. 22. Oakland won't return to the Coliseum until Nov. 3, with four road games, a bye and a "home" game against Chicago in London on Oct. 6.
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Mahomes throws 4 TD passes in the 2nd
Patrick Mahomes connects with Mecole Hardman, Travis Kelce and Demarcus Robinson twice to score four Chiefs' touchdowns in the second quarter vs. the Raiders.