The Steelers plan to put their hands on Gronkowski at every chance while inside the 5-yard cushion that allows defensive contact on receiving routes.
Safety Mike Mitchell said Gronkowski is the best tight end in the world, but added, "He has success when people don't put their hands on him."
That's why a key matchup in the game is Gronkowski versus the Steelers' inside linebackers. Pro Bowler Lawrence Timmons has had success in man-to-man coverage, and second-year linebacker Ryan Shazier is a rangy defender in zone coverage.
The Steelers will likely mix and match both looks.
"You just have to jam him up a little bit, mess with his timing," Shazier said. "If you mess up their timing, they are really time-oriented. You have to mess up their timing and get in his face with pressure, then I feel we can slow him down a little bit."
Gronkowski has 54 touchdowns in 65 regular-season NFL games -- an average of 0.83 touchdowns per game. The Patriots will be without receiver Brandon LaFell, so it's more incentive for the defense to target Gronkowski.
Told of the Steelers' comments, Gronkowski said Monday that "you have to be ready for anything."
"Some games I get jammed the whole game, some games I never get jammed. So when we go out there and practice, we practice everything -- getting jammed, not getting jammed, how to get off it, a little move. Whatever comes, I have to be ready, go out and perform," he said.
If the Steelers' defensive front can't get to Brady, all hope of disrupting Gronkowski might be futile. But the Steelers have separated the preseason's uneven defensive performances from this week, when all starters are ready to go.
"It's about trust," defensive end Cam Heyward said.
ESPN.com's Mike Reiss contributed to this report.
Steelers leaning on Roethlisberger entering Pats game
ESPN's Bob Holtzman and Jeremy Fowler discuss the Steelers' confidence entering Week 1 despite playing without Le'Veon Bell, Martavis Bryant and Maurkice Pouncey.