Officials said the U-Haul truck driver has been hospitalized with major injuries and the Caltrans worker suffered non-life threatening injuries.
All eastbound lanes were closed for a short time, while crews removed the wreckage.
All lanes reopened shortly after 11 a.m.
Before you head out to your car, be sure to check out the ABC7 traffic maps for real-time information to help you navigate through traffic jams.