CHP said at 10:30 a.m. it was searching for the 30-year-old male driver, who fled the scene.
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Four other females inside the car were transported to John Muir Medical Center in Walnut Creek with major injuries.
CHP received the initial report at 5:14 a.m. about the crash. The gray Mazda CX-9 was traveling northbound when it traveled through the dirt median separating the two freeways and overturned several times, landing on its roof.
The 9-year-old was pronounced dead at the scene. CHP said "several" occupants in the vehicle weren't wearing seatbelts.
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CHP said anyone with information about the crash, or the whereabouts of the 30-year-old Hispanic male driver, can call the Contra Costa CHP at (925) 646-4980 or email contact information to 320investigations@chp.ca.gov to be contacted by the investigating officer.