Around 4:57 pm police responded to call about at assault at Muni's Balboa Station.
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When officers got there, the suspect fled the scene and ran onto the northoubnd I-280 freeway, according to San Francisco PD.
While running across the Geneva Ave. off-ramp, the suspect was struck and killed, police said.
"The assault victim remained on scene and is being treated for non-life threatening injuries," police said.
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California Highway Patrol will handle the fatal freeway collision, while SFPD handles the assault.
All lanes of northbound 280 are back open after a temporary closure.
Further details are not available at this time.
Stay with ABC7 News for the latest details on this developing story.