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Police said 12-year-old JinJing Ma is believed to be in "extreme danger" after she was possibly abducted by an unknown Asian woman in her 40s.
Ma, visiting America from China on a group tour, checked in at the airport before leaving the group and meeting with her potential abductor.
Ma was last seen wearing a white T-shirt, blue jeans pants and a black jacket. She has black hair, brown eyes, weighs 90 pounds and is approximately 4 feet 11 inches tall.
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The potential abductor was last seen wearing a black dress. A witness stated that he may have seen the woman meet up with Ma in New York City and give her food, a source told ABC News.