On Monday, the Office of Economic and Workforce Development and the Office of Small Business will go door-to-door to inform SoMa businesses and residents about the impact of APEC.
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Oasis Grill is right across from Moscone Center -- the central site for the APEC summit.
Restaurant co-owner Muna Zughayer says she's concerned.
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The Dreamforce Conference brought thousands of visitors and boosted her business, but she's worried extra-tight security measures for APEC will hurt her bottom line.
"Now with checkpoints, I don't know if anyone will want to go. And my employees, I'm hoping they'll be able to get through," Zughayer said.
Take a closer look at this map.
According to the Secret Service and city authorities, a four-square block section of Downtown San Francisco will be locked down around Moscone Center.
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All the major closures around Moscone Center run from Nov. 15 to Nov. 18
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This includes the area between Market and Harrison Streets, and also 2nd and 5th Streets.
Business owners and residents in the security zone around Moscone Center will have to go through screening.
"We need to bring in our vegetables. We need to bring in our meat," Zughayer said. "It may be quite impossible. There's all these checkpoints but who knows if anyone can get through."
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While city leaders say APEC could be a great opportunity to spotlight San Francisco on an international stage, there are a lot of big concerns according to the Golden Gate Restaurant Association.
"It's an issue for people in that exclusion zone. They need to get their deliveries. They need to get their staff to come to work in a timely manner, particularly staff taking BART or MUNI," said Amy Cleary, director of Policy for Golden Gate Restaurant Association.
Others wonder what food delivery drivers will do.
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"Will they be able to get in there? Will they be able to get in there for drop offs and pickups," Cleary said.
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The mayor's office says outreach is ramping up this week now that there's more information from the Secret Service on security perimeters.
"I think for some businesses, this is going to be a boom. We extended restaurant week for four days because we think we will get some business from that. But I think for the businesses in the exclusion zones, the more information they can get -- as soon as possible -- will really benefit them," Cleary said.
The mayor's office emphasizes that people can go through the secured area.
It reminds people to plan ahead, especially if they have to go through screening.
Mayor London Breed is expected to brief media on Tuesday morning on the very latest APEC preparations in San Francisco.