Los Angeles paramedics were called to his home in Hollywood for an unspecified medical aid call.
They say they rushed a 94-year-old man to a local hospital. An immediate update on his condition was not available.
The hospitalization may have been related to increased pain from a previous back injury, some reports indicated. Barker has been hospitalized in the recent past for back pain and in 2017 injured his head in a fall at his home.
Barker hosted "The Price is Right" from 1972 to 2007.
In a 50-year career on television, he was also known for hosting the Miss Universe and Miss USA pageants from 1967 to 1987.
He has also been involved in animal-rights issues across the country for decades.