Firefighters responded to the collision around 1 p.m. in the 3000 block of Orwood Road.
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Fire officials say the two who survived the crash, which included a child, suffered major injuries. One of them was flown to John Muir while the other was transported by ground.
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Department officials say they are called out to this location at least once or twice a year because this is a train crossing without a traffic guard.
The cause of the crash is under investigation.
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