The crash was first reported around 4:35 p.m. on eastbound Highway 4 at Balfour Road.
At least one person has died, but it's not yet clear whether any other injuries have been reported.
An officer could be seen administering a field sobriety test on a man at the scene who was ultimately arrested.
A Sig-alert was issued for traffic in both directions around 4:50 p.m.