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A CHP spokesperson said the motorcycle officer was struck at 3:09 p.m. by a Cadillac sedan at the intersection of Harrison and Third Streets.
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The officer was taken by medics to San Francisco General Hospital with non-life-threatening injuries. The driver of the Cadillac was also taken to the hospital.
The CHP spokesperson said it wasn't clear if there were any traffic violations involved during the collision. Investigators were still on the scene at 6:40 p.m.
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Stay with ABC7 News for the latest details on this developing story.