The collision happened at the intersection of Fruitdale and Leigh Avenues Sunday afternoon.
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One of the vehicles was overturned and both nearly ended up on the sidewalk.
One adult male driver was pronounced dead at the scene.
The other driver and a female passenger were transported to the hospital with life-threatening injuries. Police said at 6:01 p.m. both were in critical condition.
A juvenile passenger was also transported to a local hospital with major injuries that police said were non-life threatening.
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