No one was injured when a car was shot at near Lakeshore Avenue.
Investigators said it started when the victims tailgated the shooter's vehicle then made a rude gesture as they passed.
The shooter then pulled alongside them, rolled down the window and opened fire.
"Try and avoid any kind of situation like this where you're making rude gestures and things of that nature," said Officer John Fransen of the Oakland police department. "Not that it excuses any of this."
The investigation caused a massive backup as Eastbound lanes were closed for about an hour.