It happened on westbound Interstate 80 near Treasure Island, just after 2 p.m.
According to the California Highway Patrol, at least three cars were involved.
CHP confirms to ABC7 news that they detained one woman in connection with this crash.
SKY7 video shows officers searching through a car before before placing her in handcuffs.
Woman detained in connection to Bay Bridge crash: CHP
Authorities also said two of the cars involved left the scene with one coming back sometime later.
Multi-car crash causes major traffic issues on Bay Bridge
The crash blocked all but one lane but has since been cleared.
Stay with ABC7 News for more on this developing story.