It happened near Gray Whale Cove, south of Devils Slide.
Firefighters battling the CZU Lightning Complex Fire rescued one person from that SUV, which got wedged between peaks.
The victim was in critical condition when rushed to San Francisco General Hospital, where CHS says he passed away.
Investigators haven't said what they believe caused the driver to go over the cliff.
Stay with ABC7 News for the latest details on this developing story.