The initial crash happened around 1:40 a.m. morning on Southbound I-880 near 66th Avenue.
At least one person was killed and another was injured. ABC7 News has calls out to the California Highway Patrol for more information.
While traffic was backed up because of the deadly crash, another accident happened at around 3:30 a.m. involving at least 10 vehicles.
One woman, whose car was struck in the second crash, said she was at a dead-stop and was hit by a fast-moving car.
The road has since been cleared and reopened following the accidents.