The fire was reported at 4:05 a.m. in a four-story building in the 3800 block of Harrison Street.
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When firefighters arrived, strong flames were burning the building and several people were evacuated.
A wall heater ignited a blanket in a first floor unit and the fire then spread to the second and third floors, Battalion Chief Ian McWhorter said.
No other buildings were damaged.
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The building was left severely damaged and 14 people were displaced. Outside the building, two residents were treated for smoke inhalation and released.
One person suffered a minor cut to the leg that was treated with a bandaid, McWhorter said.