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CHP says that units responded to a reported crash around 10:30 p.m. and found the driver with gunshot wounds.
The driver was pronounced dead on scene. It was determined that the person had died on the highway, but the shooting had taken place in the city of Oakland.
CHP Golden Gate has handed over the investigation to Oakland police.
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The freeway was closed for over five hours overnight, but as of 5 a.m. all lanes are back open.