Denton owned multiple nightclubs including, most famously, the Starlight Room atop the historic Sir Francis Drake Hotel.
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His family says Denton died Sunday in Seattle, where he had been living under the care of his brother after a stroke years ago, according to the San Francisco Chronicle.
Denton was beloved by nearly everyone he came across, and a vocal defender of the city's LGBTQ community.
Harry Tom Denton was born Nov. 3, 1943 and raised in Kimberly, Idaho, outside of Twin Falls, according the Chronicle.
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A memorial service is pending.