It happened just after 4 a.m. on the northbound lanes.
The CHP says the suspect car was speeding when it rear-ended a Nissan. The driver of the Nissan lost control and hit a guard rail.
That driver and one of the passengers died. A second passenger was taken to the hospital.
Three passengers in the suspect car were also hurt.
The CHP says the driver of that car was 21-year-old Esteban Aguilar Jimenez of San Jose.
He was taken to the hospital and faces charges including felony DUI.