According to the California Highway Patrol, the shooting took place around noon on the highway, west of Lone Tree Way.
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Authorities say someone in the SUV, possibly a 1990s Mitsubishi, shot at the victim's pickup truck three times before leaving the scene.
The Golden Gate division of the highway patrol is now investigating the freeway shooting.
RELATED: Shooting investigation shuts down part of Highway 4 in Antioch
The shooting is believed to have been targeted, according to the CHP.
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Part of the highway in Antioch was shutdown Friday afternoon while officers were investigating.
Those with information on what happened should contact the CHP tip line at 707-917-4491.