Officials say a minor collision happened between two cars, then a third car approached and made an unsafe turn. The third vehicle crashed, rolled over and a person from the car was ejected and died.
The conditions of the other drivers involved are unknown.
The CHP says to expect delays near Embarcadero Road. There is no estimated time the lanes will reopen.
SKY7 was above the fatal scene in Palo Alto showing many cars on the road during the Bay Area shelter-in-place.
SKY7: Hwy 101 lanes closed after fatal Palo Alto wreck
Stay with ABC7 News for the latest details on this developing story.