The collision was reported just east of Eden Canyon Road at 4:10 a.m., according to the California Highway Patrol.
A black sedan collided with a big-rig, affecting the driver's ability to steer the vehicle. The first big-rig came to rest in the middle of the freeway and was subsequently struck by a second big-rig, according to CHP officer Tyler Hahn.
The man driving the second big-rig died as a result of the collision. Further information about the victims was not immediately available.
Officials said there are residual delays as personnel are at the scene currently unloading one of the trucks.
A Sig-alert is no longer in effect.
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ABC7 News contributed to this story.