The crash was first reported at 5:49 a.m. on the highway at Cherry Glen Road.
A commercial van that contained flammable gas caught fire after a collision but the gas tanks did not explode, CHP Officer David Harvey said.
The collision closed all lanes of Highway 80 in both directions. The eastbound lanes reopened by around 7 a.m. and the westbound lanes reopened about an hour later, according to the CHP.